Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The urgency of this issue is primarily due to the fact that the religious component occupies an important place in the socio-cultural matrix of modern wars and military conflicts. An analysis of these wars and military conflicts allows us to assert that, despite the "antiquity" of the concepts of war, which are generated within different religious traditions, these concepts not only retain their "power" for a long historical time, but also have the capacity for modification and modernization. It is necessary (...) to know the genesis of views on war, as religious beliefs and ideas are often removed from the historical context as a basis for modern political and military doctrines, that is, interpreted in the most favorable sense in terms of the ideological goals of certain movements. (shrink)

In the coverage of the problems of war and peace in Catholicism, researchers sometimes omit the regional component of their manifestation. We are talking about local traditions in Catholicism, which have their own specific approach to solving this problem and sometimes may differ significantly from the "conventional" position. The study of this field is necessary because in the delineated field the position of those theologians who were on the "outskirts" of Catholicism in the intercultural dialogue, on the one hand, led (...) to a deviation from the humanistic orientation about Catholicism. the war. An example would be the concept of a "holy war" of the Crusades, which had the anti-Islamic rhetoric generated not only in the West but also in the East. (shrink)

Harris presents Spinoza’s philosophy as an attempt to ground a total and coherent system of the universe that preserves the integrity and freedom of finite beings as modes of God the all inclusive Substance. Traditionally, Spinoza has perhaps been too often caricatured been as a sterile rationalist clinging adamantly to the priority of mathematical knowledge and its method of strict deduction. Harris rectifies this view by clarifying and reinterpreting his theory of knowledge, the metaphysical foundations of the concept of Substance, (...) the discrepancies in the mind-body relationship, and he evaluates Spinoza’s ethical and political theories in light of his total enterprise. (shrink)